![]() ![]() In one clinical study, a scale called the Clinical Global Impression of Change was used to measure the change in EDS that people had after taking Xyrem for 8 weeks. Xyrem also reduced EDS in adults using the drug. ![]() In comparison, people taking a placebo (no active drug) had 4 fewer cataplexy episodes each week. During treatment, adults who took either 6 g or 9 g of Xyrem each night had between 10 and 16 fewer cataplexy episodes each week. In clinical trials, Xyrem was effective in treating narcolepsy by reducing both EDS and cataplexy. Xyrem is available in one strength: 0.5 grams per milliliter (g/mL). It’s usually taken at bedtime and then again, 2.5 to 4 hours later. Xyrem comes as a solution that’s taken by mouth. This helps to decrease sleepiness when you’re not at rest. Xyrem is thought to work by increasing the amount of time that your body spends in a deep sleep when you’re resting. Xyrem contains the drug sodium oxybate, which belongs to a class of medications called central nervous system (CNS) depressants. It’s approved for this use in adults and children ages 7 years and older. Xyrem treats narcolepsy by reducing both cataplexy and excessive daytime sleepiness (EDS). It can also cause sleep paralysis (the inability to move while you’re sleeping). Narcolepsy may cause hallucinations or cataplexy (sudden muscle weakness or paralysis). And it can cause you to feel extremely tired when you’re not at rest. This condition is a sleep disorder that affects how well you’re able to sleep. Xyrem is a brand-name prescription drug that’s FDA-approved to treat narcolepsy. ![]()
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